Chemical constituents from the aerial parts of Stephania tetrandra and their potential targets and activities
10.3969/j.issn.1001-1528.2024.09.022
- VernacularTitle:粉防己地上部分化学成分及其潜在作用靶点及活性研究
- Author:
Jia-Yun XUE
1
;
Wan GUO
;
Yun KANG
;
Jian-Ming HUANG
;
Ya-Qin WANG
Author Information
1. 复旦大学药学院,上海 201203
- Keywords:
Stephania tetrandra S.Moore;
aerial parts;
chemical constituents;
isolation and identification;
potential targets;
PharmMapper
- From:
Chinese Traditional Patent Medicine
2024;46(9):2980-2986
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from the aerial parts of Stephania tetrandra S.Moore and predict their potential targets and activities.METHODS The 70%ethanol extract from the aerial parts of S.tetrandra was isolated and purified by macroporous resin,silica gel,Sephadex LH-20 and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The potential targets and activities of the compounds were predicted by the PharmMapper platform.RESULTS Eleven compounds were isolated and identified as 6S,6a S-N-neolitsine Nα-oxide(1),neolitsine(2),dicentrine(3),nantenine(4),oxonantenine(5),oxophoebine(6),N-acetylnordicentrine(7),liriodenine(8),6R,6a S-N-nantenine Nβ-oxide(9),oxocrebanine(10),stigmast-4-ene-6β-ol-3-one(11).The potential targets of compounds include insulin-like growth factor 1 receptor and transthyretin.CONCLUSION Compound 1 is a new compound,and compounds 6,8-11 are isolated from this plant for the first time.Compounds 1-11 exhibit the potential activities of inhibiting a variety of tumor cells.
