Clinical effects of Modified Shugan Qingzhi Decoction on patients with type 2 diabetes mellitus complicated with dyslipidemia
10.3969/j.issn.1001-1528.2024.09.017
- VernacularTitle:疏肝清脂方加减对2型糖尿病合并脂代谢异常患者的临床疗效
- Author:
Zuan-Yi ZHONG
1
;
Hui-Fen ZHANG
;
Wan-Rong YANG
Author Information
1. 东莞市中医院内分泌科,广东 东莞 523000
- Keywords:
Shugan Qingzhi Decoction;
conventional treatment;
type 2 diabetes mellitus;
dyslipidemia
- From:
Chinese Traditional Patent Medicine
2024;46(9):2954-2958
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the clinical effects of Modified Shugan Qingzhi Decoction on patients with type 2 diabetes mellitus complicated with dyslipidemia.METHODS One hundred and sixty patients were randomly assigned into control group(80 cases)for 8-week intervention of conventional treatment,and observation group(80 cases)for 8-week intervention of both Shugan Qingzhi Decoction and conventional treatment.The changes in clinical effects,lipid metabolism indices(TC,TG,LDL-C,HDL-C,Chemerin,ApoA1,ApoB,LPa),glucose metabolism indices(FBG,2 hPG,HbA1c),irisin,food ingestion inhibitor-1,TCM syndrome scores and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed increased HDL-C,irisin(P＜0.05),and decreased TC,TG,LDL-C,Chemerin,ApoA1,ApoB,LPa,glucose metabolism indices,food ingestion inhibitor-1,TCM syndrome scores(P＜0.05),especially for the observation group(P＜0.05).No significant difference in incidence of adverse reactions was found between the two groups(P＞0.05).CONCLUSION For the patients with type 2 diabetes mellitus complicated with dyslipidemia,Modified Shugan Qingzhi Decoction can safely and effectively regulate glucose and lipid metabolism and levels of irisin,feeding inhibition factor-1,Chemerin.
