Clinical effects of Modified Mahuang Lianqiao Chixiaodou Decoction on patients with chronic eczema
10.3969/j.issn.1001-1528.2024.09.015
- VernacularTitle:麻黄连翘赤小豆汤加减对慢性湿疹患者的临床疗效
- Author:
Qing-Xing WANG
1
;
Bu-Xin ZHANG
;
Sheng-Dong XU
;
Li WANG
;
Jing LI
;
Ai-Min LIU
Author Information
1. 河南省中医院/河南中医药大学第二附属医院皮肤科,河南 郑州 450002
- Keywords:
Modified Mahuang Lianqiao Chixiaodou Decoction;
Levocetirizine Hydrochloride;
chronic eczema;
"Four-in-One"therapy
- From:
Chinese Traditional Patent Medicine
2024;46(9):2943-2949
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the clinical effects of Modified Mahuang Lianqiao Chixiaodou Decoction on patients with chronic eczema.METHODS One hundred and ninety-five patients were randomly assigned into Chinese medicine group(65 cases)for 3-week administration of Modified Mahuang Lianqiao Chixiaodou Decoction,western medicine group(65 cases)for 3-week administration of Levocetirizine Hydrochloride,and combined group(65 cases)for 3-week administration of both Modified Mahuang Lianqiao Chixiaodou Decoction and Levocetirizine Hydrochloride.The changes in clinical effects,clinical indices(EASI score,DQOLS score,TCM syndrome score,PINS score),skin physiological function indicesssss(OCTS,TEWL,WCTC),inflammatory factors(EOT,EOS,NK-κB,CCR3),T lymphocyte subsets(Treg,Th1,Th17,Th22),p38MAPK signaling pathway indices(ERK1,ERK2,mMEK 1,MEK2),recurrence rate and incidence of adverse reactions were detected.RESULTS The combined group demonstrated higher total effective rate than the Chinese medicine group and the western medicine group(P＜0.05),along with lower recurrence rate(P＜0.05).After the treatment,the combined group displayed lower EASI score,TCM syndrome score,PINS,TEWL,inflammatory factors,Th1,Th17,Th22 and p38MAPK signaling pathway indices than the control group(P＜0.05),along with higher DQOLS score,OCTS,WCTC,Treg(P＜0.05).The Chinese medicine group exhibited lower incidence of adverse reactions than the other two groups(P＜0.05).CONCLUSION For the patients with chronic eczema,Modified Mahuang Lianqiao Chixiaodou Decoction can safely and effectively alleviate skin lesion degree,enhance skin physiological functions,improve T lymphocyte subset,inflammatory factors levels,and regulate p38MAPK signaling pathway based on"Four-in-One"therapy,which exhibits synergistic effect when combined with Levocetirizine Hydrochloride.
