Consistency of chemical constituents between formula granules and standard decoction of Coptidis Rhizoma
10.3969/j.issn.1001-1528.2024.09.002
- VernacularTitle:黄连配方颗粒与标准汤剂化学成分一致性研究
- Author:
Dai-Liang ZHANG
1
,
2
;
Xin-Na DONG
;
Lei SHI
;
Xiao-Di DONG
;
Yong-Qiang LIN
;
Rong-Fei ZHANG
;
Jing-Hua ZHANG
;
Yuan-Cheng YAO
;
Feng-Chao ZHANG
;
Gui-Yun CAO
;
Zhao-Qing MENG
Author Information
1. 山东中医药大学,山东 济南 250355
2. 山东宏济堂制药集团股份有限公司,山东 济南 250103
- Keywords:
Coptidis Rhizoma;
formula granules;
standard decoction;
HPLC characteristic chromatograms;
cluster analysis
- From:
Chinese Traditional Patent Medicine
2024;46(9):2851-2858
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the consistency of chemical constituents between formula granules and standard decoction of Coptidis Rhizoma.METHODS Eighteen batches of standard decoctions were prepared,after which the extraction rate and contents,transfer rates of magnolflorine,jatrorrhizine,columbamine,epiberberine,coptisine,palmatine,berberin were determined,HPLC characteristic chromatograms were established.RESULTS There were 11 common peaks in the characteristic chromatograms of 18 batches of standard decoctions and 24 batches of formula granules with the similarities of 0.861-1.000,which were clusterd into two categories.The formula granules and standard decoction demonstrated approximated extraction rate and contents,transfer rates of index constituents.CONCLUSION The chemical constituents between formula granules and standard decoction of Coptidis Rhizoma display good consistency,which can provide references for the quality control,process research and clinical application of the former.
