A Clinical and Histopathologic Study of Thirteen Cases of Phenytoin Induced Drug Eruption.
- Author:
Ki Shik SHIN
;
Ki Beom PARK
;
Kwang Hyun CHO
;
Yoo Shin LEE
- Publication Type:Original Article
- Keywords:
Drug eruption;
Phenytoin
- MeSH:
Dermis;
Drug Eruptions*;
Eosinophils;
Epidermis;
Erythema;
Keratinocytes;
Liver;
Phenytoin*;
Seoul;
Skin
- From:Korean Journal of Dermatology
1987;25(5):599-605
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The study comprises 13 cases of phenytoin induced drug eruption admitted and treated at Seoul National University Hospital during a 6-year period (1981-1986). The summaries are as follows : 1. The skin lesions were usually pruritic morbilliform maculopapular eruptions on face, trunk, extremites, including palms and soles. However, erythema multiform was observed in one case. 2. Hiistopathologically, the dermis showed perivascular accumulation of mononuclear cells with occasional eosinophils. In some cases, the epidermis showed vacuolar alteration of basaI layer, necrotic keratinocyte with dermal perivascular mononuclear cell infiltrations. 3. The frequencies of the associated features were as follows : fever(61.5%), lymphadenopathy(23.1%), leukocytosis(45.5%), esinophilia(72.7%), and liver function abnormalities(63.6%)
