Clinical effects of Shiyan Prescription on patients with ulcerative colitis due to Bowel Dampness-Heat Stagnation
10.3969/j.issn.1001-1528.2024.08.015
- VernacularTitle:实炎方对湿热蕴肠型溃疡性结肠炎患者的临床疗效
- Author:
Li HUANG
1
;
Wei YANG
;
Yun-Hua PENG
;
Tian CHEN
;
Yan-Ni PEI
;
Hong LU
Author Information
1. 上海中医药大学研究生院,上海 201203
- Keywords:
Shiyan Prescription;
Mesalazin Enteric-coated Tablets;
ulcerative colitis;
Bowel Dampness-Heat Stagnation
- From:
Chinese Traditional Patent Medicine
2024;46(8):2591-2595
- CountryChina
- Language:Chinese
-
Abstract:
AIM To explore the clinical effects of Shiyan Prescription on patients with ulcerative colitis due to Bowel Dampness-Heat Stagnation.METHODS Eighty-two patients were randomly assigned into control group(41 cases)for 8-week administration of Mesalazin Enteric-coated Tablets,and observation group(41 cases)for 8-week administration of both Shiyan Prescription and Enteric-coated Tablets.The changes in clinical effects,TCM syndrome scores,serum inflammatory factors(interleukin-6,interleukin-22,interleukin-33),intestinal mucosal barrier function indices(diamine oxidase,D-lactic acid,endotoxin),intestinal flora(Escherichia coli,Enterococcus,Bifidobacterium,Lactobacillus)and GQOLI-74 scores were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the two groups displayed decreased TCM syndrome scores,serum inflammatory factors,intestinal mucosal barrier function indices(P＜0.05),increased GQOLI-74 scores(P＜0.05),reduced Enterococcus(P＜0.05),and enhanced Bifidobacterium,Lactobacillus(P＜0.05),especially for the observation group(P＜0.05).CONCLUSION For the patients with ulcerative colitis due to Bowel Dampness-Heat Stagnation,Shiyan Prescription can enhance life quality with obvious clinical effects.
