Chemical constituents from Codonopsis pilosula in Shanxi and their anti-inflammatory activities
10.3969/j.issn.1001-1528.2024.07.024
- VernacularTitle:潞党参化学成分及其抗炎活性研究
- Author:
Yan-Gang CHENG
1
;
Pei LI
;
Si-Qi YANG
;
Xiang-Peng KONG
;
Hui-Feng LI
;
Yan WANG
;
Jin-Yan TAN
;
Ying-Li WANG
Author Information
1. 山西中医药大学,山西 晋中 030619
- Keywords:
Codonopsis pilosula(Franch.)Nannf in Shanxi;
chemical constituents;
isolation and identification;
anti-inflammatory activities
- From:
Chinese Traditional Patent Medicine
2024;46(7):2265-2271
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Codonopsis pilosula(Franch.)Nannf in Shanxi and their anti-inflammatory activities.METHODS The 70％ ethanol extract from C.pilosula in Shanxi was isolated and purified by silica gel,ODS and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.Their in vitro anti-inflammatory activities were evaluated by RAW264.7 model.RESULTS Sixteen compounds were isolated and identified as ethylsyringin(1),7-O-ethyltangshenoside Ⅱ(2),triandrin(3),trans-isoconiferin(4),methylsyringin(5),9-acetoxy syringin(6),cordifolioidyne B(7),codonopiloenynenoside A(8),codonopilodiynoside F(9),pratialin B(10),lobetyolinin(11),lariciresinol-4-O-β-D-glucoside(12),dihydrodehydrodiconiferyl alcohol 4′-O-β-D-glucoside(13),atractylenolid Ⅲ(14),baimantuoluoamide B(15),benzyl primeveroside(16).Compounds 1-2,5,7-11 and 13-15 had certain anti-inflammatory activities,among which compounds 11,14-15 had higher activities,whose IC50 values were(18.23±4.18),(17.73±3.12),(14.89±2.47)μmol/L,respectively.CONCLUSION Compounds 3,6,13,16 are first isolated from Campanulaceae,2,5,15 are first found from this plant.Compounds 11,14 and 15 have good anti-inflammatory activities.
