Chemical constituents from Solanum lyratum and their anti-tumor activities
10.3969/j.issn.1001-1528.2024.07.022
- VernacularTitle:白毛藤化学成分及其抗肿瘤活性研究
- Author:
Lin-Guo ZHANG
1
;
Fu-An WANG
;
Man-Hua QIAO
;
Li-Ya HAO
;
Li LIU
Author Information
1. 平顶山学院医学院,河南 平顶山 467000
- Keywords:
Solanum lyratum Thunb.;
chemical constituents;
isolation and identification;
anti-tumor activities
- From:
Chinese Traditional Patent Medicine
2024;46(7):2252-2258
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Solanum lyratum Thunb.and their anti-tumor activities.METHODS The extract from S.lyratum was isolated and purified by silica gel column chromatography and Sephadex LH-20,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The anti-tumor activities were determined by MTT mothod.RESULTS Twenty-one compounds were isolated and identified as royleanone(1),dinbutyl phthalate(2),dipentyl phthalate(3),sativan(4),2′,4′-dihydroxy-chalcone(5),isopetasin(6),balanophonin(7),10-eicosenoic acid(8),4,6,7-trimethoxy-5-methyl-coumarin(9),hydroxydihydrobovolide(10),axillarin(11),xanthocyanin(12),magnoflorine(13),verlinic acid(14),apigenin(15),luteolin(16),7-ketositosterol(17),pinoresinol(18),bavachinine(19),bisbenzopyran(20),isotachioside(21).The IC50 values of compounds 6-7,11 and 18-19 ranged from(28.37±3.71)to(73.26±8.61)μmol/L.CONCLUSION All the compounds are first isolated from this plant.Compounds 6-7,11 and 18-19 have certain anti-tumor activities.
