Clinical effects of Yiqi Shengjin Prescription on patients with primary Sj?gren's syndrome due to Dual Deficiency of Qi and Yin
10.3969/j.issn.1001-1528.2024.06.013
- VernacularTitle:益气生津方对气阴两虚型原发性干燥综合征患者的临床疗效
- Author:
Zhong-Fu TANG
1
;
Chuan-Bing HUANG
;
Li-Li CHENG
;
Jun-Jie CHEN
;
Shuang-Shuang SHANG
;
Si-Di LIU
;
Ming LI
Author Information
1. 安徽中医药大学第一附属医院,安徽合肥 230031
- Keywords:
Yiqi Shengjin Prescription;
conventional treatment;
primary Sj?gren's syndrome;
Dual Deficiency of Qi and Yin
- From:
Chinese Traditional Patent Medicine
2024;46(6):1857-1861
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the clinical effects of Yiqi Shengjin Prescription on patients with primary Sj?gren's syndrome due to Dual Deficiency of Qi and Yin.METHODS Ninety-two patients were randomly assigned into control group(46 cases)for 8-week intervention of conventional treatment,and observation group(46 cases)for 8-week intervention of both Yiqi Shengjin Prescription and conventional treatment.The changes in clinical effects,TCM syndrome scores,ESSDAI score,ESSPRI score,salivary flow rate,immunoinflammatory indices(ESR,hs-CRP,IgG,C3,C4),SAS score,SDS score,T lymphocytes(CD4+,CD8+,Treg,Th17)and safety indices were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05).After the treatment,the observation group exhibited decreased TCM syndrome scores(P＜0.05),which was lower than those in the control group(P＜0.05);the two groups displayed decreased ESSDAI score,ESSPRI score,ESR,hs-CRP,IgG,SAS score,SDS score,CD8+,Th17(P＜0.05),and increased salivary flow rate,C3,C4,Treg(P＜0.05),especially for the observation group(except for CD4+)(P＜0.05).No obvious adverse reactions were observable in the two groups.CONCLUSION For the patients with primary Sjogren's syndrome due to Deficiency of Qi and Yin,Yiqi Shengjin Prescription can safely and effectively improve dry mouth and eye symptoms,and reduce inflammatory indices,whose mechanism may contribute to the regulation of T lymphocyte balance in vivo.
