Chemical constituents of dichloromethane fraction from Hypericum perforatum

VernacularTitle:贯叶金丝桃二氯甲烷部位的化学成分研究
Author: Yi-Yun ZHANG ^{1
,

2} ; Zhu-Zhen HAN ; Qian ZHANG ; Jia WANG ; Ming-Sai CHENG ; Zhen-Zhong WANG ; Ying-Bo YANG ; Wei XIAO
Author Information

1. 南京中医药大学康缘中药学院,江苏南京 210023
2. 中药制药过程控制与智能制造技术全国重点实验室,江苏连云港 222001
Keywords: Hypericum perforatum L.; dichloromethane fraction; chemical constituents; isolation and identification
From: Chinese Traditional Patent Medicine 2024;46(5):1552-1558
CountryChina
Language:Chinese
Abstract: AIM To study the chemical constituents of dichloromethane fraction from Hypericum perforatum L.METHODS The dichloromethane fraction from H.perforatum was isolated and purified by silica gel,ODS,Sephadex LH-20,semi-preparative HPLC and etc.The structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Eleven compounds were isolated and identified as hypernorpoleketone A(1),α-onocerin(2),(3R)-thunberginol C(3),2-geranyloxy-1-(2-methylpropanoyl)-phloroglucinol(4),4,6-dihydroxy-2-O-(3″,7″-dimethyl-2″,6″-octadienyl)-1-(2′-methylbutanoyl)benzene(5),norhyperpalum G(6),garsubellin A(7),garsubellin B(8),(2″R/S)-kellerine C(9),kobusone(10),eriodictyol(11).CONCLUSION Compound 1 is a new compound.Compounds 2-3 are isolated from the plants of family Guttiferae for the first time.Compounds 4-10 are isolated from this plant for the first time.