Iatrogenic Subcutaneous Aspergillosis in a Patient with Lumbar Spondylitis Treated with Ketoconazole.
- Author:
Dong Seok KIM
;
Sung Hwa KIM
;
Sang Won KIM
- Publication Type:Case Report
- Keywords:
Subcutaneous aspergillosis;
Ketoconazole;
Iatrogenic
- MeSH:
Adrenal Cortex Hormones;
Adult;
Amphotericin B;
Anti-Bacterial Agents;
Aspergillosis*;
Aspergillus fumigatus;
Diagnosis;
Exudates and Transudates;
Female;
Follow-Up Studies;
Humans;
Ketoconazole*;
Neurologic Manifestations;
Spondylitis*;
Wounds and Injuries
- From:Korean Journal of Dermatology
1987;25(5):643-648
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report herein s case of subcutaneous aspergillosis in a 41-year-old woman with lumbar spondylitis(L4~L5). The patient had received high doses of corticosteroids and broad-spectrum antibiotics and two times of operation due to lumbar problems. The diagnosis of Aspergillus fumigatus infection was established by the mycologic study of cultures from wound exudate and histopathologic examination of the second surgical specimens of subcutaneous soft tissue, which was assumed to be iatrogenically susceptible infection. Intravenous amphotericin B therapy was discontinued because of the immediste adverse effects. After twelve-week therapy of oral ketoconazole(400mg/day), open wound healed and spondylitis with neurologic signs eventually resolved. No evidence of recurrent infection was noted during six months of follow-up.
