Effects of Moluodan Dami Pills on chronic atrophic gastritis rats
10.3969/j.issn.1001-1528.2024.05.010
- VernacularTitle:摩罗丹大蜜丸对慢性萎缩性胃炎大鼠的影响
- Author:
Meng-Lei WANG
1
,
2
;
Yi-Feng WU
;
Jian-Liang SUI
;
Miao-Miao YIN
;
Hui-Yun LIU
;
Qi-Chao LIU
;
Zhuo-Chen WU
;
Zhen WANG
Author Information
1. 河北省中成胃药创新研究重点实验室,河北 邯郸 056000
2. 邯郸制药股份有限公司,河北 邯郸 056000
- Keywords:
Moluodan Dami Pills;
chronic atrophic gastritis;
PG Ⅰ/PG Ⅱ;
inflammation
- From:
Chinese Traditional Patent Medicine
2024;46(5):1476-1482
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of Moluodan Dami Pills on chronic atrophic gastritis(CAG)rats and their mechanism.METHODS The rat models were randomly divided into the model group,the low-dose group and high-dose Moluodan Dami Pills groups(2.43 g/kg and 4.86 g/kg),and vitamin A group(0.32 g/kg),following the 16 weeks successful induction of CAG by five-factor modeling method,in contrast to another 10 normal rats of the control group.After 8 weeks corresponding administration,the rats of each group had their general physiological status and pH value of gastric juice assessed;their pathological changes of gastric mucosa observed by naked eyes combined with HE staining;their changes of gastrin-secreting cells(G cells)and somatostatin-secreting cells(D cells)in gastric mucosa observed by immunohistochemistry;and their serum levels of pepsinogen Ⅰ/pepsinogen Ⅱ(PG Ⅰ/PG Ⅱ)ratio,TNF-α and IL-6 detected by ELISA.RESULTS Compared with the model group,the groups intervened with Moluodan Damei Pills and vitamin A displayed lower pH values of gastric juice(P＜0.05),improved pathological changes of gastric mucosa,increased G and D cells counts(P＜0.05,P＜0.01),increased ratio of serum PGⅠ/PGⅡ,and decreased levels of IL-6 and TNF-α(P＜0.05,P＜0.01).CONCLUSION Moluodan Dami Pills can effectively improve the symptoms of CAG rats through its influence on the number and secretion abilityof G and D cells,the levels of serum PG Ⅰ/PG Ⅱ ratio and inflammatory factors.
