Evaluation for pharmacokinetic properties and bioequivalency of Yexiazhu Formula Granules and Decoction
10.3969/j.issn.1001-1528.2024.05.006
- VernacularTitle:叶下珠配方颗粒、饮片汤剂药动学特性及生物等效性评价
- Author:
Xian-Mu ZHU
1
;
Qun HUANG
;
Dan CHEN
;
Ping XIE
;
Guo-Ping MA
Author Information
1. 福建中医药大学药学院,福建 福州 350122
- Keywords:
Yexiazhu Formula Granules;
Yexiazhu Decoction;
pharmacokinetic properties;
bioequivalency;
UPLC-MS/MS
- From:
Chinese Traditional Patent Medicine
2024;46(5):1451-1456
- CountryChina
- Language:Chinese
-
Abstract:
AIM To evaluate the pharmacokinetic properties and bioequivalency of Yexiazhu Formula Granules and Decoction.METHODS Twelve rats were randomly assigned into two groups and given intragastric administration of the solutions of Yexiazhu Formula Granules and Decoction(0.428 2,2.000 g/kg),respectively,after which blood collection was made at 0.083,0.167,0.25,0.5,0.75,1,2,3,4,8,12,24,36 h,UPLC-MS/MS was adopted in the plasma concentration determination of gallic acid,corilagin and ellagic acid,and main pharmacokinetic parameters were calculated.Subsequently,the bioequivalency of these two preparations was investigated.RESULTS No significant differences in AUC0-∞,AUC0-t,MRT0-∞,MRT0-t,t1/2,Tmax,CL and Cmax were observable between the two preparations(P＞0.05),whose Cmax,AUC0-∞ ratios or logarithmic mean differences accorded with bioequivalence standard at the 90%confidence level.CONCLUSION Yexiazhu Formula Granules and Decoction demonstrate approximate pharmacokinetic properties and display bioequivalency.
