SEPT 12 in male infertility:Advances in studies
10.13263/j.cnki.nja.2024.11.011
- VernacularTitle:胞裂蛋白12在男性不育中的研究进展
- Author:
Hai-Xia CHEN
1
;
Jing ZHANG
;
Xiao-Huan MU
;
Wen-Yan TIAN
Author Information
1. 天津医科大学总医院妇产科生殖医学中心/天津市女性生殖健康与优生重点实验室,天津 300052
- Keywords:
male fertility;
SEPT1 2;
annulus;
sperm morphological abnormality
- From:
National Journal of Andrology
2024;30(11):1030-1035
- CountryChina
- Language:Chinese
-
Abstract:
SEPT1 2,as a member of the septin gene family,is preferentially expressed in the adult male testis and plays an im-portant role in the spermatogenesis and maturation of sperm.It is also essential for the maintenance of the structural integrity of the sperm tail.SEPT12 is closely related to sperm morphological abnormality,and its mutation leads to decreased fertility or infertility of males.This review presents an overview of the advances in and affords a prospect of the studies on the structure and biological functions of SEPT12 and the impact of its mutation on male fertility.
