Proteomics of Oligoasthenoteratozoospermia:Progress in research

VernacularTitle:关于少弱畸形精子症蛋白组学的研究进展
Author: Jie ZHANG ¹ ; Miao-Yong YE ; Guo-Bing LIN
Author Information

1. 浙江中医药大学附属第一临床医学院,浙江杭州 310053
Keywords: proteomics; sperm; sperm motility; oligoasthenoteratozoospermia; infertility
From: National Journal of Andrology 2024;30(10):931-935
CountryChina
Language:Chinese
Abstract: Oligoasthenoteratozoospermia(OAT)is a common male infertility condition characterized by a decreased sperm count and poor sperm motility.The pathogenesis of OAT is rather complicated,involving such factors as lifestyle,genetic abnormalities,en-vironmental pollutants,and others.In recent years,significant progress has been made in the study of sperm proteomics,particularly in its application to the diagnosis and treatment of OAT.This review summarizes the advances in the proteomic studies of sperm and se-minal plasma in OAT patients,provides an overview of the potential differentially expressed proteins associated with sperm count and motility,aiming for a deeper insight into the pathogenesis of OAT and improvement of its diagnosis and identification of its related new biomarkers.