Treatment of male immune infertility by traditional Chinese medicine:A meta-analysis
10.13263/j.cnki.nja.2024.06.010
- VernacularTitle:中医药治疗男性免疫性不育meta分析
- Author:
Chun-Mei FAN
1
;
Si-Qi MA
;
Ke-Fan DING
;
Yi-Jian YANG
;
Xin-Bang WEN
;
Zi-Qin ZHAO
;
Shu-Hui CHEN
;
Guo-Zheng QIN
Author Information
1. 云南中医药大学第一临床医学院,云南 昆明 650021
- Keywords:
traditional Chinese medicine;
male immune infertility;
meta-analysis;
efficacy;
safety
- From:
National Journal of Andrology
2024;30(6):547-563
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of traditional Chinese medicine(TCM)in the treatment of male im-mune infertility(MII)by meta-analysis.Methods:We retrieved randomized controlled trial(RCT)on the treatment of male im-mune infertility with traditional Chinese medicine from the databases of WanFang,Chinese Biomedical Literature,Cochrane Library,Weipu,PubMed and CNKI,and performed methodological quality assessment of the RCTs identified and statistical analysis and evalua-tion of the publication bias using the RevMan5.4 software.Results:Totally,25 RCTs(2 563 cases)were included in this study.Compared with Western medicine alone in the treatment of MII,TCM achieved a significantly higher total effectiveness rate(OR=6.35,95% CI:4.96-8.13,P<0.000 01),negative conversion rate of seminal plasma anti-sperm antibodies(OR=4.52,95% CI:2.72-7.51,P<0.000 01),negative rate of serum anti-sperm antibodies(OR=2.98,95% CI:2.23-3.96,P<0.000 01),sperm concentration(MD=15.56,95% CI:11.32-19.79,P<0.000 01),grade a sperm motility(MD=3.85,95% CI:1.91-5.79,P=0.000 01),grade a+b sperm motility(MD=13.77,95% CI:7.06-20.48,P<0.000 1),sperm viability(MD=10.32,95% CI:6.78-13.86,P<0.000 01)and pregnancy rate(OR=3.53,95% CI:2.68-4.63,P<0.000 01),but a lower rate of adverse reactions(OR=0.06,95% CI:0.01-0.23,P<0.000 01).There was no statistically significant difference in the percentage of morphologically abnormal sperm between TCM and Western medicine alone in the treatment of MII(MD=-7.53,95% CI:-15.50-0.44,P=0.06).Conclusion:TCM has a definite effectiveness and high safe in the treatment of male immune infertility.
