Factors affecting the postoperative prognosis of penile cancer
10.13263/j.cnki.nja.2024.06.004
- VernacularTitle:影响阴茎癌患者术后预后因素的研究
- Author:
Yu-Shu WU
1
;
Zhi-Lei ZHANG
;
Tao ZHU
;
Zong-Yang LI
;
Zhi-Fan GUO
;
Yun-Jiang ZANG
Author Information
1. 山东第二医科大学临床医学院,山东 潍坊 261041
- Keywords:
penile cancer;
prognosis;
neutrophil-to-lymphocyte ratio;
cancer-specific survival
- From:
National Journal of Andrology
2024;30(6):507-513
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors affecting the prognosis of penile cancer after surgery.Methods:We retrospectively analyzed the clinical data on 112 cases of penile cancer treated in Weifang People's Hospital from January 2013 to De-cember 2023.Using the Kaplan-Meier survival curve,χ2 test,Fisher's exact test,and univariate and multivariate Cox risk regression analyses,we compared the clinical characteristics among different groups,and determined the independent prognostic risk factors for cancer-specific survival(CSS)of the patients.Results:The 1-,3-and 5-year CSS rates of the penile cancer patients were 78.2%,66.1% and 63.7%,respectively.Kaplan-Meier analysis indicated a significant correlation of a higher neutrophil-to-lymphocyte ratio(NLR)with a lower CSS rate(P<0.001).Multivariate Cox regression analysis showed high NLR(HR=2.6;95% CI:1.031-6.558;P=0.043)to be an independent risk factor for CSS.Conclusion:Preoperative NLR is an independent risk factor for the prognosis of penile cancer.In addition,older age,farmer or worker occupation,lower education,preoperative lymphocyte-to-monocyte ratio(LMR)≤2.81,preoperative fibrinogen(FIB)≥3.41 g/L,advanced tumor stage and tumor differentiation are associated with the poor prognosis the malignancy.
