Effect and safety of pulsatile GnRH therapy for male congenital hypogonadotropic hypogonadism
10.13263/j.cnki.nja.2024.05.003
- VernacularTitle:GnRH脉冲治疗男性先天性低促性腺激素性性腺功能减退症的有效性和安全性分析
- Author:
Yong-Hua NIU
1
;
Hao XU
;
Yin-Wei CHEN
;
Ru-Zhu LAN
;
Tao WANG
;
SHAO-Gang WANG
;
Ji-Hong LIU
Author Information
1. 华中科技大学同济医学院附属同济医院,小儿外科,湖北武汉 430030
- Keywords:
pulsatile GnRH therapy;
congenital hypogonadotropic hypogonadism;
spermatogenesis
- From:
National Journal of Andrology
2024;30(5):404-409
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficiency and safety of the pulsatile GnRH therapy in the treatment of male congeni-tal hypogonadotropic hypogonadism(CHH).Methods:We retrospectively analyzed the clinical data on 45 CHH males treated by pulsatile GnRH therapy in our hospital from January 2013 to March 2023.We treated the patients with gonadorelin at 7-15 μg,one pulse/90 min,and followed them up every month in the first 3 months and then every 3 to 6 months after treatment,for an average of 19.1±4.3 months,during which we recorded the height,body weight,penile length,testis volume,Tanner stages,levels of FSH,LH and T,semen parameters and adverse reactions of the patients,followed by comparison of the data obtained with the baseline.Results:The levels of FSH,LH and T of the patients were dramatically elevated after treatment(P<0.01).The T level of the6 ca-ses of cryptorchidism,however,failed to reach the normal value within 18.2±8.6 months of follow-up.Significant improvement was seen in the external genitalia and secondary sexual characteristics of all the patients,and spermatogenesis was observed in the semen in 33 cases(73.3% ),with a mean sperm concentration of(18.2±6.2)106/ml,sperm progressive motility of(19.7±6.5)%,and semen volume of(1.8±0.6)ml.Eight of the cases achieved natural fertility,and another 3 achieved childbirth by assisted re-productive technology.As for adverse events,gynecomastia was observed in 8,subcutaneous induration in 6,and allergic reaction to therapeutic agent in 3 cases.Conclusion:Pulsatile GnRH therapy is an effective and safe strategy for male CHH.However,clini-cians should choose appropriate approaches to different individual cases.
