Myasthenia in Acquired Neuromyotonia.
- Author:
Jung Ick BYUN
1
;
Hye Jin MOON
;
Yoon Ho HONG
Author Information
- Publication Type:Case Report
- Keywords: neuromyotonia; myasthenia; neuromuscular junction
- MeSH: Antibodies; Isaacs Syndrome*; Myasthenia Gravis; Neuromuscular Junction; Peripheral Nerves; Potassium Channels, Voltage-Gated
- From:Journal of Clinical Neurology 2014;10(1):69-71
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND: Acquired neuromyotonia (NMT) forms part of the spectrum of acquired peripheral nerve hyperexcitability syndrome, and is thought to be caused by antibodies to voltage-gated potassium channels (VGKC). Exertional weakness is unusual unless autoimmune myasthenia gravis (MG) is superimposed. CASE REPORT: A case of acquired NMT accompanied by exertional weakness without coexistence of seropositive MG is reported herein. CONCLUSIONS: Clinical and electrophysiological observations suggest that the cholinergic overactivity in NMT can compromise the safety factor sufficiently to cause a defect in neuromuscular junction transmission.
