Transperineal versus transrectal ultrasound-guided prostate biopsy in detection of clinically significant and insignificant prostate cancer:A prospective randomized controlled trial
10.13263/j.cnki.nja.2024.01.004
- VernacularTitle:经直肠与经会阴途径前列腺穿刺对临床显著性和非显著性前列腺癌检出率的前瞻性随机对照试验
- Author:
Wei-Yong LIU
1
;
Tao WANG
;
Dan-Dan MA
;
Peng WANG
Author Information
1. 中国科学技术大学附属第一医院/安徽省立医院超声科,安徽合肥 230001
- Keywords:
ultrasound;
prostate biopsy;
clinically significant prostate cancer;
clinically insignificant prostate cancer
- From:
National Journal of Andrology
2024;30(1):26-31
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare transperineal prostate biopsy(TPB)with transrectal ultrasound-guided prostate biopsy(TRUSB)in detection of clinically significant prostate cancer(csPCa)and insignificant PCa(insPCa).Methods:We conducted a prospective randomized clinical study on 279 patients receiving TPB(n=144)or TRUSB(n=135)from January 2022 to January 2023,and compared the detection rates of csPCa and insPCa between the two groups.Results:The detection rate of PCa was signifi-cantly higher in the TPB than in the TRUSB group(37.50％vs 28.15％,P=0.026).There were no statistically significant differ-ences between the TPB and TRUSB groups in the detection rates of insPCa(6.94％[n=10]vs 4.45％[n=6],P＞0.05)and csPCa(30.56％[n=44]vs 23.70％[n=32],P＞0.05),nor in the detection rate of csPCa between different groups of age,PSA concentration and prostate volume(P＞0.05).No statistically significant differences were observed between the TPB and TRUSB groups either in the positive rate of biopsy punctures([16.44±2.86]％vs[12.48±2.39]％,P＞0.05)or in the bi-opsy-related complications of urinary retention,urinary tract infection,hematuria and rectal bleeding(P＞0.05).Conclusion:TPB is more effective than TRUSB in detection of PCa,but there is no statistically significant difference between the two approaches in the detection rates of csPCa and insPCa.
