Inhibitory Effect of TGJN on α1-Adrenoceptor of Human Hypertrophic Prostate in vitro
10.3969/j.issn.1009-3591.2001.02.026
- VernacularTitle:通关胶囊对离体人增生前列腺α1-AR的拮抗作用
- Author:
ZHANG SHUWU
1
;
CHANG DEGUI
;
WANG JIUYUAN
;
GUO KAI
;
SHAO JICHUN
Author Information
1. Chengdu University of Traditional Chinese Medicine
- From:
National Journal of Andrology
2001;7(2):136-138，140
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To evaluate the mechanism of using TGJN(a kind of extract of Chinese herb medicine)to treat BPH. Methods: The radioligandbinding assays were used to observe the inhibiting effect from TGJN to the α1-AR in human smooth muscle cells of hyperplastic prostate. Results: TGJN can inhibit the binding of α1-AR with 125 I BE through binding with α1-AR.The inhibition was related to the concentration of TGJN and the inhibition was the biggest in middle lobe of human hyperplastic prostate[The Ki was (200.3±19.83)mg/L]. Conclusions: TGJNcan inhibit the α1-AR in human smooth muscle cells of hyperplastic prostate. Natl J Androl,2001,7(2):136～138
