Progestin and Male Reproduction
10.3969/j.issn.1009-3591.2001.02.013
- VernacularTitle:孕激素与男性生殖
- Author:
JIA YUE
1
;
CUI YUGUI
;
DI FUSONG
Author Information
1. the First Affiliated Hospital Nanjing Medical University
- From:
National Journal of Andrology
2001;7(2):117-120
- CountryChina
- Language:Chinese
-
Abstract:
Progestin has been used as a hormone therapy for some prostatic diseases,suchas benign prostatic hyperplasia and prostatic cancer, and as a hormone regimen formale contraception with or without androgen.This article reviewed the physiologicaland pharmacological effects of progestin on male reproduction.Progestin inhibits thehypothalamus-pituitary-gonadal axis by the negative feedback.All the malereproductive organs highly expressed progesterone receptor (PR) mRNA, whichsuggested that progestin played some important roles in these organs.Humanspermatogenic cells and spermatozoa contained definite amount of progesterone (P)and 17 α-hydroxyprogesterone,which suggested an association between these steroidsand spermatogenesis and fertilization.A hormonal regimen consisting of progestinplus testesterone has been confirmed as an effective,safe,and reversible malecontraception.Though pharmacological dosages of progestin inhibited the expressionof androgen-dependant sexual behaviors,physiological levels progesterone couldstimulate sexual and copulatory behaviors.Some pregnane derivations have a highlyinhibitary effect on the enzyme 5 alphareductase type 2,which showed the benefit onthe treatment of prostatic diseases. Natl J Androl, 2001,7(2):117～120
