Advances in Phospholipid Hydroperoxide Glutathione Peroxidase and Sperm Maturation
10.3969/j.issn.1009-3591.2001.02.011
- VernacularTitle:磷脂过氧化氢物谷胱甘肽过氧化物酶与精子成熟
- Author:
LI WEITAO
1
;
ZHU WEIJIE
;
PAN SHANPEI
Author Information
1. Jinan University
- From:
National Journal of Andrology
2001;7(2):109-112
- CountryChina
- Language:Chinese
-
Abstract:
The gene encoding selenoprotein phospholipid hydroperoxide glutathioneperoxidase (PHGPx) is located in chromosome 19 in human. PHGPx is the secondidentified as Se-dependent intracellular glutathione peroxidase (PHGPx) which is a19000(Mr), monomeric enzyme. PHGPx originally presumed to be a universal antioxidantenzyme protecting membrane lipids, appears to have adopted a variety of specificroles like silencing lipoxygenases and becoming an enzymatically inactive structuralcomponent of the mitochondrial capsule during sperm maturation. In other words,PHGPx exists as a soluble peroxidase in spermatids but persists in maturespermatozoa as an enzymatically inactive, oxidatively cross-linked, insolubleprotein. Natl J Androl,2001,7(2):109～112
