The 507th case: hemolytic anemia, parvovirus B19, and multiple organ dysfunction
10.3760/cma.j.cn112138-20231210-00376
- VernacularTitle:第507例——溶血性贫血、细小病毒B19感染、多器官功能障碍
- Author:
Yang LIU
1
;
Xiaohui ZHANG
;
Leqing CAO
;
Xiaojun HUANG
;
Xiaodong MO
Author Information
1. 北京大学人民医院 北京大学血液病研究所 国家血液系统疾病临床医学研究中心，北京 100044
- Keywords:
Anemia, hemolytic;
Parvovirus B19, human;
Acute B cell lymphoblastic leukemia;
Haplo-stem cell transplantation
- From:
Chinese Journal of Internal Medicine
2024;63(7):720-723
- CountryChina
- Language:Chinese
-
Abstract:
A 19-year-old male patient with high-risk acute B-cell lymphoblastic leukemia received haploidentical stem cell transplantation. He developed anemia repeatedly and parvovirus B19 nucleic acid was positive in blood plasma. The patient was diagnosed with cold agglutinin syndrome and multiple organ dysfunction including respiratory failure and hepatitis. In the conflict between viral infection and the treatment of cold agglutinin syndrome, we provided supportive treatment, complement inhibitors to control hemolysis, and antiviral therapy. After timely glucocorticoid and immunosuppressant therapy, the patient had achieved a good response.
