Research progress of RANKL signaling pathway in glucose metabolism
10.3760/cma.j.cn311282-20240730-00337
- VernacularTitle:RANKL信号通路在糖代谢中的研究进展
- Author:
Xintian LIU
1
;
Yikun ZHU
Author Information
1. 山西医科大学第二医院内分泌科，太原 030001
- Keywords:
RANKL;
Diabetes mellitus;
Glucose metabolism;
Insulin resistance;
Mechanism
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(11):981-984
- CountryChina
- Language:Chinese
-
Abstract:
The RANKL/RANK/OPG signaling pathway is essential for balancing bone resorption and bone formation. Research shows this signaling pathway exists in various tissues, including liver, muscle, adipose tissue, pancreas, and other tissues that might influence glucose metabolism. Blocking the pathway could protect islet β cell function. Furthermore, RANKL also improves insulin resistance by inducing beige adipocytes differentiation and increasing energy expenditure. Currently, the role of RANKL in glucose metabolism remains controversial. This article reviews current research and discusses the potential use of RANKL inhibitors for treating diabetes with osteoporosis.
