Enhancing research on immunotherapy for pituitary neuroendocrine tumors
10.3760/cma.j.cn311282-20240625-00283
- VernacularTitle:加强垂体神经内分泌肿瘤的免疫治疗研究
- Author:
Shaojian LIN
1
;
Junchen WU
;
Zhebao WU
Author Information
1. 上海交通大学医学院附属瑞金医院神经外科，上海 200025
- Keywords:
Pituitary neuroendocrine tumors;
Immunotherapy;
Tumor heterogeneity;
Immune microenvironment;
Multi-omics analyses
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(11):920-922
- CountryChina
- Language:Chinese
-
Abstract:
Despite advancements in endoscopic treatment for pituitary neuroendocrine tumors(PitNETs), refractory PitNETs remain challenging due to their invasiveness, incomplete resection, and recurrence, with suboptimal outcomes from current therapeutic modalities. Immunotherapy, which enhances anti-tumor immune responses, presents a promising approach for managing refractory PitNETs. Single-cell sequencing has recently revealed tumor heterogeneity and immune microenvironment characteristics of PitNETs, providing a foundation for immunotherapy applications. Studies have revealed that immune infiltration varies across PitNET subgroups, offering insights for targeted immunotherapy. However, challenges persist, including a lack of validated immunotherapeutic targets, limited clinical trials, monotonous approaches, and uncertain efficacy. Future research should prioritize multi-omics analyses to identify new targets, expand basic and clinical research, explore diverse immunotherapeutic strategies, and develop personalized and combination therapies.
