Association of systemic immunity-inflammation index with the risk of hyperuricemia: A cohort study
10.3760/cma.j.cn311282-20240306-00086
- VernacularTitle:系统免疫炎症指数与新发高尿酸血症相关性的队列研究
- Author:
Xiaoling XIE
1
;
Xinlei MIAO
;
Manling HU
;
Shuang LIU
;
Ziping SONG
;
Yuting SUN
;
Guimin TANG
;
Qianqian WANG
;
Song LENG
Author Information
1. 大连医科大学附属第二医院健康管理中心 116023
- Keywords:
Systemic immunity-inflammation index;
Hyperuricemia;
Cohort study;
Health examination
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(10):844-850
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between systemic immunity-inflammation index(SII) and hyperuricemia(HUA).Methods:Participants who had at least 3 health checkups in the Health Management Center of the Second Affiliated Hospital of Dalian Medical University from January 2014 to December 2022 were selected to construct a dynamic cohort. The SII, reflecting the inflammatory state of the body, was constructed using neutrophil, platelet, and lymphocyte counts. A Cox proportional hazard regression model was used to explore the association between SII and HUA in the overall population and different subgroups of the population, and sensitivity analysis was performed twice. Results:A total of 20 022 subjects were included, and the mean follow-up time was 3.67 years. After adjusting for confounding factors, each unit increase in the natural logarithm of SII(lnSII) was associated with a 24% increased risk of hyperuricemia( HR=1.24, 95% CI 1.16-1.32, P<0.001). As a categorical variable, compared with the lowest quartile array( Q1), the risk of HUA in the total population increased by 12%( HR=1.12, 95% CI 1.03-1.21, P=0.006), 14%( HR=1.14, 95% CI 1.06-1.24, P=0.001), 27%( HR=1.27, 95% CI 1.17-1.37, P<0.001) in Q2, Q3 and Q4 groups within the general population, respectively. All subgroup analysis and sensitivity analysis showed that SII was positively correlated with HUA. Conclusions:Elevated levels of SII significantly increase the risk of HUA. Assessing the body′s inflammatory status using SII can aid in risk screening and preventive management for individuals at high risk of HUA.
