CD9 + CD55 low adipose progenitor cells contribute to the development of type 2 diabetes

VernacularTitle:CD9 +CD55 low脂肪前体细胞促进2型糖尿病发生
Author: Hongdong WANG ¹ ; Yanhua DU ; Shanshan HUANG ; Xitai SUN ; Haixiang SUN ; Xuehui CHU ; Lei SHEN ; Yan BI
Author Information

1. 南京大学医学院附属鼓楼医院内分泌科　210008
Keywords: Diabetes mellitus, type 2; Stromal cell; Adipose progenitor cell; Single cell sequencing
From: Chinese Journal of Endocrinology and Metabolism 2024;40(10):830-834
CountryChina
Language:Chinese
Abstract: Adipose progenitor cells(APCs) represent a prominent stromal cellular component of adipose tissue and are now identified as highly heterogenous populations. However, the role of APCs in regulating systemic metabolism remains unknown. Using single cell RNA-sequencing, we investigated the role of the APC subpopulations in regulating development of type 2 diabetes. CD9 + CD55 low APCs are the novel subset identified in this study, which is significantly increased in type 2 diabetic patients. Transplantation of these cells from type 2 diabetic patients into adipose tissue caused glycemic disturbance in mice. Depletion of pathogenic APCs improved obesity-related glycemic disturbance. Collectively, our data provide deeper insights into human APC functionality and highlights APCs as a potential therapeutic target to combat type 2 diabetes. This study has been published in Nature Communications, 2024, 15(1): 4827.