Insulin resistance caused by iatrogenic hyperinsulinemia in type 1 diabetes

VernacularTitle:1型糖尿病医源性高胰岛素血症致胰岛素抵抗的研究进展
Author: Shuang LI ¹ ; Jingfei LIU ; Yang CHEN ; Yong GU ; Tao YANG
Author Information

1. 南京医科大学第一附属医院内分泌科，南京　210029
Keywords: Diabetes mellitus, type 1; Iatrogenic hyperinsulinemia; Insulin resistance
From: Chinese Journal of Endocrinology and Metabolism 2024;40(9):811-816
CountryChina
Language:Chinese
Abstract: Type 1 diabetes is characterized by an absolute deficiency of insulin. Exogenous insulin replacement therapy is a crucial treatment approach for type 1 diabetes. However, the non-physiological insulin administration can lead to iatrogenic hyperinsulinemia, exacerbate peripheral insulin resistance, and subsequently increase the risk of various complications. Emerging insulin infusion technologies, lifestyle interventions, and medications such as metformin are increasingly being utilized in type 1 diabetes management to lower plasma insulin levels and improve patient outcomes.