Association of obesity and chronic kidney disease: A retrospective cohort study
10.3760/cma.j.cn311282-20231115-00170
- VernacularTitle:肥胖与慢性肾脏病的关联：一项回顾性队列研究
- Author:
Xiaoling XIE
1
;
Xinlei MIAO
;
Guimin TANG
;
Qianqian WANG
;
Manling HU
;
Ziping SONG
;
Shuang LIU
;
Song LENG
Author Information
1. 大连医科大学附属第二医院健康管理中心，大连 116023
- Keywords:
Chronic kidney disease;
Obesity;
Cohort study;
Health examination;
Restricted cubic spline
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(9):752-757
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between obesity and incident chronic kidney disease(CKD) in a population undergoing health check-ups.Methods:This is a retrospective cohort study. A total of 31 251 participants who had at least 2 health physical examinations in the Health Management Center of the Second Affiliated Hospital of Dalian Medical University from January 2017 to December 2022 and met the inclusion criteria were selected. The participants were divided into normal body weight group, overweight group, and obese group according to baseline body mass index. Cox proportional hazard regression model was used to analyze the relationship between obesity and new-onset CKD, and the dose-response relationship between body mass index and CKD was analyzed with restricted cubic splines.Results:Multivariate Cox regression analysis showed that the risk of developing CKD increased by 13%( HR=1.13, 95% CI 1.01-1.25) and 55%( HR=1.55, 95% CI 1.36-1.76) in the overweight and obese group compared to the normal weight group. Subgroup analysis indicated that obese women had a higher risk of developing CKD compared to men. There was a " U-shaped" correlation between body mass index and CKD in male population, with the lowest risk of CKD occurring at body mass index of 19.6-24.2 kg/m 2. In women, the relationship between body mass index and CKD was approximately linear, with the risk of CKD gradually increasing when body mass index exceeded 22.5 kg/m 2. Conclusions:Obesity is an independent risk factor for new-onset CKD, and obese women have a higher risk of developing CKD than men. Regarding CKD prevention, men are advised to maintain a higher level of body weight within the normal range of body mass index, while women are encouraged to control their weight to a lower level within the normal body mass index range.
