The regulatory role of the hypothalamus in the thermogenesis of brown and beige adipose tissue
10.3760/cma.j.cn311282-20230925-00094
- VernacularTitle:下丘脑在棕色脂肪组织和米色脂肪组织产热过程中的调控作用
- Author:
Hongli DU
1
;
Huan YAN
;
Bingyin SHI
;
Yanan WANG
Author Information
1. 西安交通大学第一附属医院MED-X研究院，免疫代谢性疾病研究所，西安 712000
- Keywords:
Adipose tissue;
Energy metabolism;
Thermogenesis;
Hypothalamus;
Metabolic diseases
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(8):719-726
- CountryChina
- Language:Chinese
-
Abstract:
There are three types of adipose tissue: white adipose tissue that stores energy, brown adipose tissue that expends energy, and beige adipose tissue which results from the browning of white adipose tissue. Research has established that adipose tissue is vital for energy metabolism. However, the complex regulatory mechanisms limit the development of effective therapeutic strategies for obesity and related metabolic diseases. This review explores the characteristics and functions of adipose tissue types, emphasizing the role of central hypothalamic nuclei in regulating peripheral adipose tissue function Additionally, it provides a summary and comparison of current research on leveraging brown and beige adipose tissue thermogenesis as a treatment for metabolic diseases, offering insights for the advancement of targeted therapies for obesity and related disorders.
