Progress on obesity-induced hypothalamic GnRH neuron dysfunction
10.3760/cma.j.cn311282-20240410-00142
- VernacularTitle:肥胖损伤下丘脑GnRH神经元功能的研究进展
- Author:
Mei LIU
1
;
Leilei YANG
;
Qian YANG
;
Qingbo GUAN
;
Chunxiao YU
Author Information
1. 内分泌糖脂代谢与脑老化教育部重点实验室，山东第一医科大学附属省立医院内分泌代谢病科，济南 250012
- Keywords:
Fertility;
Obesity;
GnRH neurons
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(7):625-634
- CountryChina
- Language:Chinese
-
Abstract:
The declining fertility has emerged as a significant concern impacting national welfare, with obesity identified as a major contributing factor. In the hypothalamus, gonadotropin-releasing hormone(GnRH) neurons release GnRH, which regulates the secretion of estrogen and testosterone via the hypothalamic-pituitary-gonadal(HPG) axis, thereby influencing sexual development and fertility. The proper function of GnRH neurons is crucial for maintaining normal sexual development and fertility. Research indicates that obesity can impact GnRH neuron function through several pathways, such as disrupting pulsatile secretion core kisspeptin neurons, causing imbalance in energy sensing and metabolic factor secretion, and triggering hypothalamic inflammation. These pathways directly or indirectly influence GnRH neuron function in the hypothalamus, which ultimately affects sexual development and impairs fertility. Therefore, this review consolidates recent advancements in understanding the mechanisms by which obesity induces dysfunction in hypothalamic GnRH neurons, offering new perspectives for early clinical interventions aimed at enhancing fertility outcomes in obese individuals.
