SIGLEC-1 and type 1 diabetes autoimmune response: Emerging research

VernacularTitle:SIGLEC-1与1型糖尿病自身免疫机制：新兴研究视角
Author: Mengqi GUO ¹ ; Yangang WANG ; Shufa LI
Author Information

1. 青岛大学附属医院心血管内科　266003
Keywords: SIGLEC-1; Monocytes; Diabetes mellitus, type 1; Autoimmune response; Interferon signaling pathway
From: Chinese Journal of Endocrinology and Metabolism 2024;40(7):570-572
CountryChina
Language:Chinese
Abstract: Recent findings from Diabetologia highlight the pivotal role of sialic acid-binding immunoglobulin-type lectin 1(SIGLEC-1) positive monocytes in the early onset of type 1 diabetes. These cells activate immune effector cells primarily via the interferon signaling pathway, diverging from traditional antigen presentation methods, thereby triggering pancreatic inflammation and destruction. This discovery paves the way for novel approaches in early diagnosis and targeted therapies for type 1 diabetes.