Serum myostatin and follistatin as biomarkers of sarcopenia in elderly women
10.3760/cma.j.cn311282-20231023-00129
- VernacularTitle:血清肌肉生长抑素及卵泡抑素作为老年女性肌少症生物学标志物的研究
- Author:
Yanping DU
1
;
Ye YANG
;
Wenjing TANG
;
Minmin CHEN
;
Huilin LI
;
Weijia YU
;
Xiaoqing WU
;
Liu SHEN
;
Xuemei ZHANG
;
Yuxiang ZHENG
;
Jianfei GU
;
Qun CHENG
Author Information
1. 复旦大学附属华东医院骨质疏松科，上海 200040
- Keywords:
Myostatin;
Follistatin;
Muscle mass;
Sarcopenia;
Biomarker
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(6):500-504
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aimed to explore the clinical value of myostatin(MST) and follistatin(FST) as biological biomarkers in evaluating sarcopenia in elderly women.Methods:This was a retrospective cross-sectional study that enrolled 350 females aged 20-89 years who underwent physical examinations in Shanghai Huadong Hospital in 2021. Demographic characteristics, muscle mass, fat mass, bone mineral density, hand grip strength, gait speed, and serum indices of MST and FST were collected.Results:The serum levels of MST did not change significantly with age. However, the serum levels of FST increased with age. In women aged≥60 years, MST was positively correlated with total lean mass and appendicular skeletal muscle index(ASMI; r=0.236, P=0.041; r=0.289, P=0.014), while FST was negatively correlated with ASMI( r=-0.265, P=0.030). In multivariate stepwise regression analysis, after adjusting for age, body mass index, hip bone mineral density, and total fat mass, only FST was independently correlated with ASMI( β=-0.238, P=0.006), while MST was not correlated with ASMI. The receiver operating characteristic curve was plotted using muscle mass reduction as the state variable and serum FST level as the test variable. The area under the curve was 0.753. And when the FST cutoff value was 17.49 ng/mL, the maximum Jordan index was 0.46, with a sensitivity of 77.3% and a specificity of 68.7%. Women aged ≥60 years were divided into three groups based on serum FST levels. Compared to the upper third of the serum FST level group, the low third of the FST level group had a significantly reduced risk of suffering from sarcopenia( OR=0.098, P =0.036). Conclusions:Serum FST lever has a better correlation with muscle mass among elderly women, making it a promising biomarker for evaluating muscle mass.
