Factors affecting the self-reported life quality of patients with acromegaly
10.3760/cma.j.cn311282-20230421-00196
- VernacularTitle:肢端肥大症患者简易生活质量满意度自评分影响因素分析
- Author:
Shengmin YANG
1
;
Huijuan ZHU
;
Lian DUAN
;
Hui PAN
;
Xue BAI
;
Rui JIAO
;
Yuelun ZHANG
;
Tongxin XIAO
;
Qingjia ZENG
;
Yi WANG
;
Xinxin MAO
;
Yong YAO
;
Kan DENG
Author Information
1. 中国医学科学院，北京协和医学院，北京协和医院内分泌科，卫健委内分泌重点实验室，协和转化医学中心，北京 100730
- Keywords:
Acromegaly;
Self-reported brief life quality satisfaction score;
Biochemical remission
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(6):494-499
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore influencing factors of the self-reported brief life quality satisfaction score(Brief-QoL) in patients with acromegaly and understand the persistent low Brief-QoL scores in cases achieving biochemical remission.Methods:This study included 836 acromegaly patients who were hospitalized at Peking Union Medical College Hospital between January 2012 and December 2020. We retrospectively examined how clinical characteristics, biochemical parameters, comorbidities, and symptoms influenced Brief-QoL. Among patients who achieved biochemical remission, differences in clinical symptoms and comorbidities were analyzed between the high and low quality of life groups.Results:Patients with well-controlled biochemical indicators at the last follow-up had generally high Brief-QoL. However, patients with symptoms such as headaches (47.8% in the low-score group vs 14.9% in the high-score group, P<0.001) and joint pain (69.6% in the low-score group vs 19.0% in the high-score group, P<0.001) had low Brief-QoL despite biochemical remission. Receiving combined treatment(52.4% in the low-score group vs 27.5% in the high-score group, P=0.030) and having comorbid diabetes or hyperlipidemia were significant factors leading to decreased quality of life. Conclusion:Brief-QoL is suitable for follow-up of outpatient patients. Early identification of factors affecting quality of life and timely intervention can facilitate the realization of standardized management.
