Correlation of fibroblast growth factor 23 with insulin resistance and sex hormone levels in patients with polycystic ovary syndrome
10.3760/cma.j.cn311282-20231102-00150
- VernacularTitle:成纤维细胞生长因子23与多囊卵巢综合征患者胰岛素抵抗及性激素水平的相关性研究
- Author:
Yu LI
1
;
Zixuan TANG
;
Qi HUANG
;
Xiaoying YUAN
;
Qian WANG
;
Lin ZHANG
;
Han ZHANG
;
Ying ZHANG
;
Yachao BA
;
Dingyan LUO
;
Jiaoyang FENG
;
Xin LIAO
Author Information
1. 遵义医科大学附属医院内分泌与代谢病科 563000
- Keywords:
Polycystic ovary syndrome;
Fibroblast growth factor 23;
Insulin resistance;
Hyperandrogenemia
- From:
Chinese Journal of Endocrinology and Metabolism
2024;40(6):475-480
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of serum fibroblast growth factor 23(FGF23) level with insulin resistance(IR) and sex hormone levels in patients with polycystic ovary syndrome(PCOS).Methods:A retrospective study was performed in eighty-seven patients with PCOS, fifty-seven patients with simple IR, and sixty-one healthy women who were admitted to Affiliated Hospital of Zunyi Medical University during October 2021 and November 2022. According to the homeostasis model assessment-IR index, all subjects were divided into normal control group( n=61), IR group( n=57), PCOS without IR group(PCOS group, n=15), and PCOS+ IR group( n=72). The levels of serum FGF23, adiponectin, and sex hormones in all groups were compared, and their correlations with glucose and lipid metabolism indicators were analyzed. Results:The FGF23 level was significantly elevated in the IR group, while markedly reduced in the PCOS group and PCOS+ IR group, with the PCOS group showing a significantly lower concentration. The adiponectin levels were significantly decreased in the IR group, PCOS group, and PCOS+ IR group(all P<0.05). The correlation analysis showed that FGF23 level was positively correlated with adiponectin and sex hormone binding globulin, and negatively correlated with luteinizing hormone, luteinizing hormone/follicle stimulating hormone, and free testosterone index(all P<0.05). Logistic regression results indicated that both FGF23 and adiponectin could be used as good indicators for the diagnosis of PCOS and PCOS with IR(all P<0.05). Conclusion:FGF23 is closely related to IR and androgen as well, and under certain conditions, it can reflect the severity of IR and hyperandrogenemia in PCOS patients. The cutoff value of FGF23 obtained in this study can provide a good reference for the diagnosis of PCOS diseases.
