Effect of age factor on potency of cisatracurium-induced neuromuscular block in obese patients
10.3760/cma.j.cn131073.20231110.01116
- VernacularTitle:年龄因素对肥胖患者顺式阿曲库铵肌松效力的影响
- Author:
Yanbing LI
1
;
Qinshuang LIU
;
Zhaoheng LI
;
Yuli GUO
;
Shuang LIU
;
Yating YANG
;
Xiaochun YANG
Author Information
1. 秦皇岛市第一医院麻醉科，秦皇岛 066000
- Keywords:
Age factors;
Aged;
Obesity;
Atracurium;
Dose-response relationship, drug
- From:
Chinese Journal of Anesthesiology
2024;44(11):1366-1368
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of age factor on the potency of cisatracurium-induced neuromuscular block in the obese patients.Methods:American Society of Anesthesiologists Physical Status classification Ⅰ-Ⅲ obese patients, with a body mass index of 30-35 kg/m 2 and waist circumference (female ≥ 80 cm, male ≥ 90 cm), 40 elderly patients (age 65-75 yr) and 40 young and middle-aged patients (age 18-64 yr), scheduled for elective surgery with general anesthesia, were included in this study. Based on the random number table method, the patients were assigned into dosage groups of 40, 50, 60 and 70 μg/kg, served as OF1-4 groups and YF1-4 groups, with 10 patients in each group. The consumption of cisatracurium was calculated based on fat-free mass using a single-dose method. The neuromuscular block of cisatracurium was monitored by recording the response of the adductor pollicis muscle to TOF stimulation, the maximum suppression degree of T 1 and onset time were recorded using the Mindray BeneVision N17 monitor, and the dose-response relationship regression equation was developed to calculate the median effective dose. Results:There was no significant difference in the onset time among groups ( P>0.05). The median effective dose in elderly obese patients and young and middle-aged obese patients were 50.01 and 48.71 μg/kg, respectively, and there was no significant difference between the two groups ( P>0.05). Conclusions:There is no significant difference in the potency of cisatracurium-induced neuromuscular block between elderly obese patients and young and middle-aged obese patients, suggesting that age factor has no significant effect on it.
