Effect of preoperative chemotherapy on intraoperative hemodynamics and quality of early postoperative recovery in patients undergoing tumor resection
10.3760/cma.j.cn131073.20240327.01004
- VernacularTitle:术前化疗对肿瘤切除术患者术中血流动力学及术后早期恢复质量的影响
- Author:
Aisiaiti ABUDUSHALAMU·
1
;
Ajiaikebaier AIWUZAILI·
;
Maimaitiming AINI·
;
Qiang GENG
;
Kuerban GULIBANUMU·
;
Bing ZHANG
;
Yuanming ZHANG
Author Information
1. 新疆医科大学附属肿瘤医院麻醉与围术期医学中心，乌鲁木齐 830011
- Keywords:
Chemoradiotherapy;
Neoplasms;
Surgical procedures, operative;
Hemodynamics;
Rehabilitation
- From:
Chinese Journal of Anesthesiology
2024;44(10):1170-1174
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of preoperative chemotherapy on the intraoperative hemodynamics and quality of early postoperative recovery in patients undergoing tumor resection.Methods:This was a prospective cohort study. A total of 249 patients undergoing malignant tumor resection in the Affiliated Cancer Hospital of Xinjiang Medical University from January to August 2023 were divided into chemotherapy group (group C, n=104) and non-chemotherapy group (group N, n=145) based on their chemotherapy history. Heat rate and mean arterial pressure were recorded on admission (T 0), 1 min before endotracheal intubation (T 1), immediately after endotracheal intubation (T 2), at skin resection (T 3), 30 min after endotracheal incision (T 4), at the end of surgery (T 5) and 24 h after surgery (T 6), and the Quality of Recovery-15 score was recorded at T 6. The occurrence of hypoxemia, oropharyngeal airway implantation, bucking and aspiration after tracheal extubation was observed. The occurrence of postoperative nausea and vomiting was recorded. Results:Compared with group N, the mean arterial pressure was significantly decreased at T 1 and increased at T 2, 3, the heart rate was increased at T 2-5, the total Quality of Recovery-15 score, postoperative physical comfort score, emotional state score and pain score were decreased at T 6, and the incidence of hypoxemia and postoperative nausea and vomiting after tracheal extubation was increased in group C ( P<0.05). Conclusions:Preoperative chemotherapy can affect the intraoperative hemodynamic stability and the quality of early postoperative recovery is decreased in patients undergoing preoperative tumor resection.
