Effect of age on sedative potency of remimazolam
10.3760/cma.j.cn131073.20240320.00916
- VernacularTitle:年龄因素对瑞马唑仑镇静效力的影响
- Author:
Jin HUANG
1
;
Jiashuo ZHANG
;
Fengdan MA
;
Bowei JIANG
;
Shengyu WANG
;
Yanan HAN
;
Chunguang WANG
Author Information
1. 保定市第一中心医院麻醉科，保定 071000
- Keywords:
Age factors;
Remimazolam;
Conscious sedation;
Dose-response relationship, drug
- From:
Chinese Journal of Anesthesiology
2024;44(9):1127-1130
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of age on the sedative potency of remimazolam.Methods:This was a prospective study. Patients of either sex, aged 40-80 yr, with body mass index of 18-28 kg/m 2, of American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ, scheduled for elective surgery with general anesthesia, were divided into middle age group (40-64 yr) and elderly group (65-80 yr) based on the age of the patients. The test was performed by the Dixon′s up-and-down method. The initial dose of remimazolam was 0.3 mg/kg. The Modified Observer′s Assessment of Alertness/Sedation Scale score ≤1 and bispectral index value≤60 within 3 min after administration were considered as an effective sedation. The dose of remimazolam was increased/decreased by 0.03 mg/kg based on the sedative efficacy in the previous patient. The 50% effective dose (ED 50) and 95% confidence interval ( CI) of remimazolam were calculated by the probit method. The time to the loss of consciousness was recorded. Results:The ED 50 (95% CI) of remimazolam was 0.345 (0.306-0.384) mg/kg in middle age group, while the ED 50 (95% CI) of remimazolam was 0.322 (0.303-0.339) mg/kg in elderly group. The ED 50 was significantly higher in middle age group than in elderly group ( u=417.00, P=0.022). The time to loss of consciousness was significantly longer in elderly group than in middle age group ( t=-2.96, P=0.008). Conclusions:For middle-aged and elderly patients aged 40-80 yr, the sedative potency of remimazolam increases with age.
