Effect of preoperative mild cognitive impairment on potency of sevoflurane in inhibiting body movement responses during skin incision in aged female patients
10.3760/cma.j.cn131073.20240313.00815
- VernacularTitle:术前轻度认知功能障碍对老年女性患者七氟烷抑制切皮时体动反应效力的影响
- Author:
Lei WANG
1
;
Zhiqiang NIU
;
Sen YANG
;
Yufeng GUO
;
Min LIU
Author Information
1. 沧州市中心医院麻醉科，沧州 061001
- Keywords:
Sevoflurane;
Dose effect relationship, drug;
Cognitive dysfunction;
Aged;
Femininity
- From:
Chinese Journal of Anesthesiology
2024;44(8):977-980
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of preoperative mild cognitive impairment (MCI) on the potency of sevoflurane in inhibiting body movement responses during skin incision in aged female patients.Methods:This was a prospective study. Female American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ patients, aged 60-75 yr, with body mass index of 18.5-23.9 kg/m 2, scheduled to undergo radical mastectomy between January 2022 and March 2023 in our hospital, were selected. The patient′s cognitive function was assessed using Mini-Mental State Examination and Montreal Cognitive Assessment. The patients were divided into 2 groups based on whether they had MCI or not before operation: normal group (group N) and MCI group (group M). General anesthesia was induced by inhaling 8% sevoflurane, and the laryngeal mask airway was inserted after they lost consciousness and their jaws relaxed. According to the Dixon′s up-and-down method, the end-tidal concentration of sevoflurane in the first patient was set at 2%. If the body movement response occurred, the concentration was increased by 2% in the next patient, otherwise the concentration was decreased by 2% in the next patient. The MAC and 95% confidence interval ( CI) of sevoflurane were calculated using the probability regression method. Results:The minimum alveolar concentration of sevoflurane was 1.60% (95% CI 1.48% -1.70%) in group N and 1.38% (95% CI 1.25%-1.49%) in group M, and there was statistically significant difference ( P<0.05). Conclusions:Preoperative MCI can increase the potency of sevoflurane in inhibiting body movement responses during skin incision in aged female patients.
