Effect of heavy smoking on dose-effect relationship of ciprofol for painless gastroscopy when combined with alfentanil
10.3760/cma.j.cn131073.20240319.00712
- VernacularTitle:重度吸烟因素对复合阿芬太尼时环泊酚用于无痛胃镜检查术量效关系的影响
- Author:
Jin HUANG
1
;
Jiashuo ZHANG
;
Yanan HAN
;
Shengyu WANG
;
Fengdan MA
;
Bowei JIANG
;
Chunguang WANG
Author Information
1. 保定市第一中心医院麻醉科，保定 071000
- Keywords:
Smoking;
Ciprofol;
Alfentanil;
Gastroscopy;
Dose-effect relationship, drug
- From:
Chinese Journal of Anesthesiology
2024;44(7):826-829
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of heavy smoking on the dose-effect relationship of ciprofol for painless gastroscopy when combined with alfentanil.Methods:This was a prospective study. American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ male patients, aged 18-64 yr, with body mass index of 18-28 kg/m 2, undergoing elective painless gastroscopy from October 2023 to February 2024 in Baoding First Central Hospital, were divided into non-smoking group and heavy smoking group (smoking index>400) according to the status of smoking. Alfentanil 5 μg/kg and ciprofol were intravenously injected, and gastroscopy was performed after the patient′s eyelash reflex disappeared and the jaw was relaxed. The study was performed by the Dixon′s up-and-down method, and the initial dose of ciprofol was 0.4 mg/kg. The dose of ciprofol increased or decreased by 0.04 mg/kg each time based on the positive or negative response of the previous patient. A positive response was defined as the Modified Observer′s Assessment of Alertness/Sedation Scale score being greater than 1 point at 3 min after ciprofol injection or the occurrence of coughing, swallowing, body movement, or other responses that affected the operation during the insertion of the endoscope. The median effective dose (ED 50) and 95% confidence interval of propofol for painless gastroscopy were determined by the probit analysis. Results:Twenty-five patients were finally included in non-smoking group and 23 patients in heavy smoking group. The ED 50 (95% confidence interval) of ciprofol when combined with alfentanil was 0.205 (0.159, 0.244) mg/kg in non-smoking group and 0.252 (0.184, 0.295) mg/kg in heavy smoking group. The ED 50 was significantly higher in heavy smoking group than in non-smoking group ( u=390, P=0.009). Conclusions:Heavy smoking can weaken the sedative potency of propofol for sedation when used for painless gastroscopy when combined with alfentanil.
