The pathogenesis of anti-M3R antibody in Sjogren's syndrome complicated with interstitial cystitis
10.3760/cma.j.cn112330-20230804-00034
- VernacularTitle:抗M3R抗体在干燥综合征并发间质性膀胱炎中致病机制的研究进展
- Author:
Congying XU
1
;
Zhihui XU
;
Yasong LI
Author Information
1. 浙江中医药大学第二临床学院，杭州 310053
- Keywords:
Sjogren's syndrome;
Interstitial cystitis;
Anti-M3R antibody;
Pathogenic mechanism
- From:
Chinese Journal of Urology
2024;45(8):637-640
- CountryChina
- Language:Chinese
-
Abstract:
Sjogren's syndrome is a chronic inflammatory autoimmune disease characterized by invasion of exocrine glands such as lacrimal gland and salivary gland and high lymphocyte infiltration. Interstitial cystitis is a chronic cystitis disease with frequent micturition, urgency, nocturia and/or pelvic pain as its main clinical manifestations, and its pathological changes are bladder submucosal ulcer and fibrosis as its main manifestations. Sjogren's syndrome complicated with interstitial cystitis is not uncommon. Anti-muscarinic type 3 acetylcholine receptor (M3R) antibody will not only cause gland dysfunction, but also play an important role in the pathogenesis of interstitial cystitis. The pathogenesis may include: ①Immune inflammation accompanied by mast cells and neurogenic inflammation with up-regulation of bladder sensory nerve. ②The detrusor contraction function is impaired, which induces ATP release and stimulates sensory nerve outflow.
