Peripheral blood levels of receptor-interacting protein kinase 3, neutrophil gelatinase-associated lipocalin, and β2-microglobulin in elderly patients with chronic kidney disease and their predictive efficacy for acute kidney injury
10.3760/cma.j.issn.0254-9026.2024.11.015
- VernacularTitle:老年慢性肾脏病患者外周血受体相互作用蛋白3中性粒细胞凝胶酶相关脂蛋白和β2微球蛋白水平变化及对急性肾损伤发生的预测效能
- Author:
Liqin GUO
1
;
Haixia BU
;
Huan WANG
Author Information
1. 新乡市中心医院肾内科，新乡 453000
- Keywords:
Nephrosis;
β2-microglobulin;
Renal injury;
Receptor-interacting protein kinase 3;
Neutrophil gelatinase-associated lipocalin
- From:
Chinese Journal of Geriatrics
2024;43(11):1463-1467
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes in peripheral blood levels of receptor interacting protein kinase 3(RIP3), neutrophil gelatinase-associated lipocalin(NGAL), and β2-microglobulin(β2M)in older patients with chronic kidney disease, as well as their predictive efficacy for acute kidney injury.Methods:A retrospective analysis was conducted involving 119 older patients diagnosed with chronic kidney disease at Xinxiang Central Hospital from June 2022 to June 2024.The patients were categorized into an acute kidney injury(AKI)group(n=58)and a non-AKI group(n=61)based on the presence of acute kidney injury.General clinical data were compared between the two groups; levels of RIP3, NGAL, and β2M were quantified using enzyme-linked immunosorbent assay(ELISA).Logistic regression analysis was performed to identify multifactorial factors influencing the occurrence of acute kidney injury in older patients with chronic kidney disease.Furthermore, receiver operating characteristic(ROC)curve analysis and the area under the curve(AUC)were utilized to assess the predictive value of RIP3, NGAL, and β2M for acute kidney injury in this patient population.Results:In comparison to the non-AKI group, patients in the AKI group exhibited significantly elevated levels of serum creatinine(Scr), RIP3, NGAL, and β2M( t=2.008, 7.729, 7.680, 7.447, all P<0.05).Logistic regression analysis identified RIP3( OR=1.760, 95% CI: 1.164-2.664), NGAL( OR=1.856, 95% CI: 1.215-2.834), and β2M( OR=1.454, 95% CI: 1.118-1.891)as risk factors for acute kidney injury in older patients with chronic kidney disease(all P<0.05).Furthermore, ROC curve analysis demonstrated that RIP3, NGAL, β2M, and their combination had sensitivities of 65.52%, 94.83%, 65.52%, and 87.93%, specificities of 91.80%, 70.49%, 93.44%, and 95.08%, and AUCs of 0.833, 0.901, 0.806, and 0.975, respectively.The predictive value of RIP3, NGAL, β2M, and their combination surpassed that of individual predictors( Z=4.143, 3.305, 4.218, all P<0.001). Conclusions:The combined assessment of peripheral blood RIP3, NGAL, and β2M demonstrates superior predictive efficacy for acute kidney injury in older patients with chronic kidney disease.
