Research progress on pathogenesis of inflammatory bowel disease and stem cell therapy in the elderly

VernacularTitle:老年人炎症性肠病发病机制的研究进展与干细胞治疗
Author: Tong PAN ¹ ; Xiaoying LUO ; Yangqiu BAI ; Xiaoke JIANG ; Bingyong ZHANG
Author Information

1. 郑州大学人民医院消化内科，郑州　450000
Keywords: Crohn disease; Colitis, ulcerative; Stem cell transplantation; Immune senescence
From: Chinese Journal of Geriatrics 2024;43(10):1345-1350
CountryChina
Language:Chinese
Abstract: As China enters the aging era, the incidence rate and prevalence of inflammatory bowel disease(IBD)in the elderly have increased.The relationship between aging and inflammation appears to be more significant in elderly individuals with IBD.However, most current studies focus on describing the clinical characteristics of the disease, with limited research on its pathogenesis and treatment.In this review, we summarize the differences in clinical characteristics and treatment between elderly individuals with IBD and young individuals.We also discuss the impact of aging on elderly IBD and explore the possibility of stem cell transplantation therapy as a new approach for clinical management.Our aim is to provide fresh insights for the treatment of elderly IBD.