Research progress on prodromal multiple system atrophy
10.3760/cma.j.issn.0254-9026.2024.09.016
- VernacularTitle:前驱期多系统萎缩的研究进展
- Author:
Jing PAN
1
;
Jia KANG
;
Xin WANG
;
Rihan HAI
;
Piu CHAN
Author Information
1. 内蒙古医科大学第二附属医院神经内科，呼和浩特 010010
- Keywords:
Multiple system atrophy;
alpha-synuclein;
Differential diagnosis
- From:
Chinese Journal of Geriatrics
2024;43(9):1191-1195
- CountryChina
- Language:Chinese
-
Abstract:
Multiple system atrophy(MSA)is a rapidly progressive neurodegenerative disease and, along with Parkinson's disease(PD)and dementia with Lewy bodies(DLB), belongs to the group of α-synucleinopathies.Due to an overlap of clinical symptoms of similar diseases in the early stages and a lack of sensitivity of the current diagnostic criteria to detect the disease in the early stages, difficulties abound in conducting clinical trials on disease-modifying therapeutic agents for its early treatment, and progress in the development of disease-modifying therapeutic agents as well as the development and validation of diagnostic tools has been slow.Consequently, the International Movement Disorder Society(MDS)has introduced new diagnostic criteria for MSA, which, for the first time, propose a category known as possible prodromal MSA and its diagnostic criteria.This review described the diagnostic criteria for possible prodromal MSA and its differential diagnosis from other prodromal α-synucleinopathies, in order to improve the accuracy of diagnosis in the early stages and to promote research on the early stages of the disease.
