Analysis of factors affecting aspirin resistance in patients with cerebral infarction and its recurrence
10.3760/cma.j.issn.0254-9026.2024.08.016
- VernacularTitle:影响脑梗死患者阿司匹林抵抗的相关因素及复发情况分析
- Author:
Li CHENG
1
;
Man YANG
;
Yunyi DAI
Author Information
1. 商丘市第一人民医院康复科，商丘 476100
- Keywords:
Cerebral infarction;
Risk factors;
Recurrence;
Aspirin resistance
- From:
Chinese Journal of Geriatrics
2024;43(8):1049-1053
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of aspirin resistance(AR)on the recurrence of cerebral infarction and to analyze risk factors related to the development of AR in such patients.Methods:A retrospective study was conducted to analyze the data of 202 cerebral infarction patients admitted to Shangqiu First People's Hospital between January 2020 and January 2022.All patients were given continuous treatment in accordance with their conditions for more than one week.The AR status of the patients was examined by the turbidimetric platelet aggregation test.Based on AR status, 202 patients were divided into an AR group(63)and an aspirin-sensitive(AS)group(139).General data of the two groups were compared concerning sex, age, hypertension, diabetes, coronary heart disease, hyperlipidemia, smoking, drinking, atrial fibrillation, AR, triglycerides, total cholesterol(TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, C-reactive protein, homocysteine, compliance with antiplatelet drug therapy, and oxidized low-density lipoprotein(ox-LDL), among others.Parameters showing statistical significance in the comparison were further examined in multivariate logistic regression analysis to identify independent risk factors for the occurrence of AR in patients with cerebral infarction.The 2-year recurrence rates between the two groups were compared.Results:There were statistically significance differences in cerebral infarction recurrence, TC and ox-LDL between patients in the AR group and in the AS group( P<0.05).Subsequent multivariate logistic regression analysis showed that cerebral infarction recurrence( OR=15.410, 95% CI: 5.504-43.146, P<0.001)and TC( OR=0.454, 95% CI: 0.313-0.660, P<0.001)were independent risk factors affecting AR in patients with cerebral infarction.The 2-year recurrence rate in the AR group(11.11% or 7/63)was significantly higher than in the AS group(3.60% or 5/139)( P<0.05). Conclusions:Cerebral infarction recurrence and TC are independent risk factors for AR in patients with cerebral infarction, and AR will further increase the risk of cerebral infarction recurrence.Therefore, monitoring the presence of AR in patients has practical value in preventing cerebral infarction recurrence.
