Assessment of the aging phenomenon of the glomerular filtration rate
10.3760/cma.j.issn.0254-9026.2024.06.010
- VernacularTitle:评估肾小球滤过率增龄现象的研究
- Author:
Xiaohua PEI
1
;
Xue SHEN
;
Juan ZHANG
;
Yan GU
;
Min CHEN
;
Yao MA
;
Zhenzhu YONG
;
Yun BAI
;
Qun ZHANG
;
Weihong ZHAO
Author Information
1. 南京医科大学第一附属医院老年肾科，南京 210029
- Keywords:
Glomerular filtration rate;
Kidney diseases;
Kidney function tests;
Serum creatinine;
Aging
- From:
Chinese Journal of Geriatrics
2024;43(6):710-715
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To construct an estimating equation to accurately reflect the aging phenomenon of the glomerular filtration rate(GFR).Methods:Healthy subjects receiving physical examinations at the First Affiliated Hospital of Nanjing Medical University between January 2017 and April 2018 were included in the study, and the aging phenomenon of renal function indicators such as serum creatinine(Scr)was used as the reference standard to evaluate the accuracy of four Scr-based GFR equations during GFR aging, including the full age spectrum(FAS)equation, the Chronic Kidney Disease Epidemiology Collaboration(CKD-EPI)equation, the Osaka equation and the Xiangya equation.Results:Of 37 636 individuals receiving physical examinations, 6 534 met the criteria specified in this study.Scr, serum urea nitrogen, serum uric acid, and serum albumin showed a significant aging phenomenon( H=191.640, 196.693, 83.271, 414.585, P<0.001 for all).The GFR estimated by the four equations all decreased with aging, but the starting point and rate of decline were significantly different.The GFR aging phenomenon estimated by the FAS equation was closer to the trend of renal function indicators. Conclusions:The FAS equation may be more applicable to healthy people to understand the aging phenomenon of GFR.
