Correlation of serum ADAMTS-4 and aβ2-GPl levels with white matter lesions in elderly patients with acute cerebral infarction
10.3969/j.issn.1009-0126.2024.11.016
- VernacularTitle:两种血清标志物与老年急性脑梗死患者脑白质病变的相关性研究
- Author:
Wenli NA
1
;
Xiangdong BAI
;
Yan BAO
Author Information
1. 750001 银川市第一人民医院神经内科
- Keywords:
brain infarction;
eukoencephalopathies;
correlation of data;
anti-β2 glycoprotein 1 antibody
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(11):1325-1328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of serum levels of ADAMTS-4 and aβ2-GP1 anti-body with WML in elderly patients with ACI.Methods A retrospective study was conducted on 200 elderly ACI patients admitted in Department of Neurology of from January 2022 to January 2024.Based on Fazekas scoring,they were categorized into the control group(n=32),mild group(n=96),moderate group(n=49),and severe group(n=23).Their neurological function and ser-um levels of ADAMTS-4 and aβ2-GP1 were compared among the different groups.Results The NIHSS score and serum levels of ADAMTS-4 and aβ2-GP1 were significantly higher in the severe group than the moderate group,mild group and control group in order,and statistical difference were observed among them(P＜0.05).Serum ADAMTS-4 and aβ2-GP1 levels were significantly positively correlated with the severity of WML(P＜0.05).Serum ADAMTS-4 and anti-β2-GP1 were influencing factors for the occurrence of WML in elderly ACI patients(OR=2.149,95％CI:1.375-3.360,P=0.001;OR=1.702,95％CI:1.185-2.446,P=0.004).Conclusion The levels of serum ADAMTS-4 and aβ2-GP1 are closely related to the severity of WML and nerve damage in elderly ACI patients.
