Effect of transcranial alternating current stimulation on cerebral perfusion in patients with Alzheimer's disease using MRI 3D-ASL
10.3969/j.issn.1009-0126.2024.11.014
- VernacularTitle:基于磁共振成像三维动脉自旋标记评价经颅交流电刺激对阿尔茨海默病脑灌注的影响
- Author:
Tao WANG
1
;
Shaozhen YAN
;
Hanxiao XUE
;
Hanyu XI
;
Zhigang QI
;
Yi TANG
;
Jie LU
Author Information
1. 100053 北京,首都医科大学宣武医院放射与核医学科磁共振成像脑信息学北京市重点实验室
- Keywords:
Alzheimer disease;
transcranial alternating current stimulation;
cerebrovascular circula-tion;
magnetic resonance imaging
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(11):1315-1319
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of transcranial alternating current stimulation(tACS)on cerebral blood flow(CBF)in patients with Alzheimer's disease(AD).Methods A ret-rospective study was conducted on 21 mild AD patients admitted in our hospital from September 2019 to April 2022.All of them received tACS treatment for 3 weeks.Mini-mental state examina-tion(MMSE),auditory verbal learning test(AVLT)and MRI were applied to obtain the data at baseline(T0),the end of the treatment(T1)and in three months after treatment(T2).Z-trans-form CBF(zCBF)was performed to reduce individual variability.The changes in MMSE and AVLT scores,as well as brain zCBF and CBF values before and after tACS treatment were ana-lyzed.Spearman correlation analysis was used to examine the relationship of zCBF and CBF with cognitive scores.Results In the AD patients,their MMSE score was significantly increased at T1 than at T0[22.00(20.00,25.00)vs 20.00(18.00,21.50),P＜0.01].Based on voxel analysis,the AD patients exhibited significantly increased zCBF in the bilateral frontal and temporal cortex at T1,and in the right frontal and temporal cortex at T2 when compared with the levels at T0(P＜0.05).The most pronounced increase in zCBF was observed in the right insular.Based on region of inter-est analysis,increased zCBF and CBF in the right frontal and temporal cortex at T1 were observed(P＜0.05).There was a positive correlation between the change of CBF in the right frontal cortex and AVLT-recognition recall at T1(r=0.617,P=0.005)and between the change of CBF in the left frontal cortex and MMSE at T2(r=0.596,P=0.012).Conclusion MRI 3D-ASL can objec-tively evaluate the changes of CBF in AD patients after tACS treatment,and it provides a reliable imaging marker for evaluating the efficacy of tACS.
