Predictive value of serum indicators combined with echocardiography for heart failure in elderly patients after acute myocardial infarction
10.3969/j.issn.1009-0126.2024.11.005
- VernacularTitle:血清指标联合超声心动图检查对老年急性心肌梗死后心力衰竭的预测价值
- Author:
Xiaoyan YAN
1
;
Zhuohua ZENG
;
Kai LI
;
Yang XIE
;
Jing WU
;
Bo SHI
Author Information
1. 610051 成都医学院第二附属医院核工业四一六医院超声医学科
- Keywords:
myocardial infarction;
heart failure;
echocardiography;
forecasting;
apelin-12
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2024;26(11):1272-1276
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the predictive value of serum solitary G protein-coupled receptor ligand-12(Apelin-12)combined with echocardiographic parameters,wall motion score(WMS)and left ventricular global longitudinal strain(LV-GLS)for heart failure(HF)in elderly patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 98 elderly AMI patients undergoing PCI in our hospital from January 2021 to December 2023 were enrolled,and according to the occurrence of HF or not at 3 months after PCI,they were divided into HF group(39 cases)and non-HF group(59 cases).PCI procedure was completed within 12 h after admission,and the blood samples were collected and echocardiography was per-formed at discharge.ROC curve was plotted to evaluate the predictive value of Apelin-12,WMS and LV-GLS for HF in elderly AMI patients.Kappa consistency test was conducted to assess the accuracy of combined the three indicators in predicting HF in the patients.Results The HF group had significantly lower serum Apelin-12 level,and higher WMS and LV-GLS than the non-HF group(P＜0.01).ROC curve analysis showed that the AUC value of Apelin-12,WMS and LV-GLS in predicting HF after PCI in elderly AMI patients was 0.931,0.745 and 0.749,respec-tively,and their cut-off values was 1.55 μg/L,20.50 and-12.90％,respectively.Multivariate lo-gistic regression analysis revealed that serum Apelin-12＜1.55 μ g/L,WMS＞20.50 points,and LV-GLS＞-12.90％were independent risk factors for postoperative HF in elderly AMI patients(OR=3.508,95％CI:2.002-6.147);OR=2.818,95％CI:1.479-5.371;OR=2.841,95％CI:1.505-5.363).When the three indicators combined in tandem,that is,when serum Apelin-12＜1.55 μg/L,WMS＞20.50 and LV-GLS＞-12.90％,HF was predicted to be positive,with a speci-ficity increasing to 94.92％and a Kappa value of 0.714(P＜0.01).Conclusion Detection of serum Apelin-12,WMS and LV-GLS is beneficial for elderly AMI patients after PCI in predicting the oc-currence of HF,and can open up a new direction for clinical diagnosis and treatment.
